• Division of Microbiology (Kanda lab), Faculty of Medicine, Tohoku Medical and Pharmaceutical University

研究成果・論文

2020年
1. Okabe A, Huang KK, Matsusaka K, Fukuyo M, Xing M, Ong X, Hoshii T, Usui G, Seki M, Mano Y, Rahmutulla B, Kanda T, Suzuki T, Rha SY, Ushiku T, Fukayama M, Tan P, and Kaneda A: Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma. Nat Genet. 52(9),919-930, 2020.

2019年
2. Sugimoto A, Yamashita Y, Kanda T, Murata T, Tsurumi T: Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments. PLoS One 14:e0222519, 2019.

3. Nakayama A, Abe H, Kunita A, Saito R, Kanda T, Yamashita H, Seto Y, Ishikawa S, and Fukayama M: Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein-Barr Virus-associated gastric carcinoma. PLoS One. 14(1),e0211358, 2019.

4. *Kanda T, Yajima M, and Ikuta K: Epstein-Barr virus strain variation and cancer. Cancer Sci. 110(4),1132-1139, 2019.
論文解説はこちら

5. Yajima M, Miyata M, Ikuta K, Hasegawa Y, Oneyama C, and *Kanda T: Efficient Epstein-Barr Virus Progeny Production Mediated by Cancer-Derived LMP1 and Virally-Encoded microRNAs. Microorganisms. 7(5), 2019.
論文解説はこちら

2018年
6. *Kanda T: EBV-Encoded Latent Genes. Adv Exp Med Biol. 1045(377-394, 2018.

7. Yajima M, Ikuta K, and *Kanda T: Rapid CRISPR/Cas9-Mediated Cloning of Full-Length Epstein-Barr Virus Genomes from Latently Infected Cells. Viruses. 10(4), 2018.
論文解説はこちら

8. Sasaki S, Nishikawa J, Sakai K, Iizasa H, Yoshiyama H, Yanagihara M, Shuto T, Shimokuri K, Kanda T, Suehiro Y, Yamasaki T, Sakaida I: EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions. Gastric Cancer. 2018.

(*責任著者)

東北医科薬科大学着任前の主要論文(神田)
1. *Kanda T, Furuse Y, Oshitani H, and Kiyono T: Highly Efficient CRISPR/Cas9-Mediated Cloning and Functional Characterization of Gastric Cancer-Derived Epstein-Barr Virus Strains. J Virol. 90(9), 4383-4393, 2016.

2. *Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, and Iizasa H: Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor. J Virol. 89(5),2684-2697, 2015.

3. *Kanda T, Horikoshi N, Murata T, Kawashima D, Sugimoto A, Narita Y, Kurumizaka H, and Tsurumi T: Interaction between basic residues of Epstein-Barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance. J Biol Chem. 288(33),24189-24199, 2013.

4. *Kanda T, Ochi T, Fujiwara H, Yasukawa M, Okamoto S, Mineno J, Kuzushima K, and Tsurumi T: HLA-restricted presentation of WT1 tumor antigen in B-lymphoblastoid cell lines established using a maxi-EBV system. Cancer Gene Ther. 19(8),566-571, 2012.

5. *Kanda T, Shibata S, Saito S, Murata T, Isomura H, Yoshiyama H, Takada K, and Tsurumi T: Unexpected instability of Family of Repeats (FR), the critical cis-acting sequence required for EBV latent infection, in EBV-BAC Systems. PLoS One. 6(11),e27758, 2011.

6. Ali AK, Saito S, Shibata S, Takada K, and *Kanda T: Distinctive effects of the Epstein-Barr virus family of repeats on viral latent gene promoter activity and B-lymphocyte transformation. J Virol. 83(18),9163-9174, 2009.

7. *Kanda T, Kamiya M, Maruo S, Iwakiri D, and Takada K: Symmetrical localization of extrachromosomally replicating viral genomes on sister chromatids. J Cell Sci. 120(Pt 9),1529-1539, 2007.

8. Yajima M, Kanda T, and Takada K: Critical role of Epstein-Barr Virus (EBV)-encoded RNA in efficient EBV-induced B-lymphocyte growth transformation. J Virol. 79(7),4298-4307, 2005.

9. Ahsan N, Kanda T, Nagashima K, and Takada K: Epstein-Barr virus transforming protein LMP1 plays a critical role in virus production. J Virol. 79(7),4415-4424, 2005.

10. *Kanda T, Yajima M, Ahsan N, Tanaka M, and Takada K: Production of high-titer Epstein-Barr virus recombinants derived from Akata cells by using a bacterial artificial chromosome system. J Virol. 78(13),7004-7015, 2004.

11. Kanda T, Otter M, and Wahl GM: Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering. J Cell Sci. 114(Pt 1),49-58, 2001.

12. Kanda T, Otter M, and Wahl GM: Coupling of mitotic chromosome tethering and replication competence in Epstein-Barr virus-based plasmids. Mol Cell Biol. 21(10),3576-3588, 2001.

13. Kanda T, and Wahl GM: The dynamics of acentric chromosomes in cancer cells revealed by GFP-based chromosome labeling strategies. J Cell Biochem Suppl. 35(107-114, 2000.

14. Kanda T, Sullivan KF, and Wahl GM: Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol. 8(7),377-385, 1998.

15. Shimizu N, Kanda T, and Wahl GM: Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet. 12(1),65-71, 1996.

16. Kanda T, Segawa K, Ohuchi N, Mori S, and Ito Y: Stimulation of polyomavirus DNA replication by wild-type p53 through the DNA-binding site. Mol Cell Biol. 14(4),2651-2663, 1994.