• Division of Microbiology (Kanda lab), Faculty of Medicine, Tohoku Medical and Pharmaceutical University


1. Sugimoto A, Watanabe T, Matsuoka K, Okuno Y, Yanagi Y, Narita Y, Mabuchi S, Nobusue H, Sugihara E, Hirayama M, Ide T, Onouchi T, Sato Y, Kanda T, Saya H, Iwatani Y, Kimura H, Murata T. Growth Transformation of B Cells by Epstein-Barr Virus Requires IMPDH2 Induction and Nucleolar Hypertrophy. Microbiol Spectr. 11(4): e0044023, 2023. プレスリリースはこちら

1. Wongwiwat W, Fournier B, Bassano I, Bayoumy A, Elgueta Karstegl C, Styles C, Bridges R, Lenoir C, BoutBoul D, Moshous D, Neven B, Kanda T, Morgan RG, White RE, Latour S, Farrell PJ. Epstein-Barr Virus Genome Deletions in Epstein-Barr Virus-Positive T/NK Cell Lymphoproliferative Diseases. J Virol, 96(12): e0039422, 2022.

1. Yanagi Y, Okuno Y, Narita Y, Masud HMAA, Watanabe T, Sato Y, Kanda T, Kimura H, and Murata T: RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells. Virology. 557:44-54, 2021

2. Yajima M, Kakuta R, Saito Y, Kitaya S, Toyoda A, Ikuta K, Yasuda J, Ohta N, and *Kanda T: A global phylogenetic analysis of Japanese tonsil-derived Epstein-Barr virus strains by using viral whole-genome cloning and long-read sequencing. J Gen Virol. 102(3) 2021.  プレスリリースはこちら

1. Okabe A, Huang KK, Matsusaka K, Fukuyo M, Xing M, Ong X, Hoshii T, Usui G, Seki M, Mano Y, Rahmutulla B, Kanda T, Suzuki T, Rha SY, Ushiku T, Fukayama M, Tan P, and Kaneda A: Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma. Nat Genet. 52(9),919-930, 2020.

1. Sugimoto A, Yamashita Y, Kanda T, Murata T, Tsurumi T: Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments. PLoS One 14:e0222519, 2019.

2. Nakayama A, Abe H, Kunita A, Saito R, Kanda T, Yamashita H, Seto Y, Ishikawa S, and Fukayama M: Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein-Barr Virus-associated gastric carcinoma. PLoS One. 14(1),e0211358, 2019.

3. *Kanda T, Yajima M, and Ikuta K: Epstein-Barr virus strain variation and cancer. Cancer Sci. 110(4),1132-1139, 2019.

4. Yajima M, Miyata M, Ikuta K, Hasegawa Y, Oneyama C, and *Kanda T: Efficient Epstein-Barr Virus Progeny Production Mediated by Cancer-Derived LMP1 and Virally-Encoded microRNAs. Microorganisms. 7(5), 2019.

1. Ichikawa T, Okuno Y, Sato Y, Goshima F, Yoshiyama H, Kanda T, Kimura H, and Murata T:2018. Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells. mSphere 3(6):e00478-18, 2018.

2. *Kanda T: EBV-Encoded Latent Genes. Adv Exp Med Biol. 1045(377-394, 2018.

3. Yajima M, Ikuta K, and *Kanda T: Rapid CRISPR/Cas9-Mediated Cloning of Full-Length Epstein-Barr Virus Genomes from Latently Infected Cells. Viruses. 10(4), 2018.

4. Sasaki S, Nishikawa J, Sakai K, Iizasa H, Yoshiyama H, Yanagihara M, Shuto T, Shimokuri K, Kanda T, Suehiro Y, Yamasaki T, and Sakaida I: EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions. Gastric Cancer. 2018.

1.     Sato Y, Ochiai S, Murata T, Kanda T, Goshima F, and Kimura H: Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells. Oncotarget 8:39345-39355, 2017.


1. *Kanda T, Furuse Y, Oshitani H, and Kiyono T: Highly Efficient CRISPR/Cas9-Mediated Cloning and Functional Characterization of Gastric Cancer-Derived Epstein-Barr Virus Strains. J Virol. 90(9), 4383-4393, 2016.

2. *Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, and Iizasa H: Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor. J Virol. 89(5),2684-2697, 2015.

3. *Kanda T, Horikoshi N, Murata T, Kawashima D, Sugimoto A, Narita Y, Kurumizaka H, and Tsurumi T: Interaction between basic residues of Epstein-Barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance. J Biol Chem. 288(33),24189-24199, 2013.

4. *Kanda T, Ochi T, Fujiwara H, Yasukawa M, Okamoto S, Mineno J, Kuzushima K, and Tsurumi T: HLA-restricted presentation of WT1 tumor antigen in B-lymphoblastoid cell lines established using a maxi-EBV system. Cancer Gene Ther. 19(8),566-571, 2012.

5. *Kanda T, Shibata S, Saito S, Murata T, Isomura H, Yoshiyama H, Takada K, and Tsurumi T: Unexpected instability of Family of Repeats (FR), the critical cis-acting sequence required for EBV latent infection, in EBV-BAC Systems. PLoS One. 6(11),e27758, 2011.

6. Ali AK, Saito S, Shibata S, Takada K, and *Kanda T: Distinctive effects of the Epstein-Barr virus family of repeats on viral latent gene promoter activity and B-lymphocyte transformation. J Virol. 83(18),9163-9174, 2009.

7. *Kanda T, Kamiya M, Maruo S, Iwakiri D, and Takada K: Symmetrical localization of extrachromosomally replicating viral genomes on sister chromatids. J Cell Sci. 120(Pt 9),1529-1539, 2007.

8. Yajima M, Kanda T, and Takada K: Critical role of Epstein-Barr Virus (EBV)-encoded RNA in efficient EBV-induced B-lymphocyte growth transformation. J Virol. 79(7),4298-4307, 2005.

9. Ahsan N, Kanda T, Nagashima K, and Takada K: Epstein-Barr virus transforming protein LMP1 plays a critical role in virus production. J Virol. 79(7),4415-4424, 2005.

10. *Kanda T, Yajima M, Ahsan N, Tanaka M, and Takada K: Production of high-titer Epstein-Barr virus recombinants derived from Akata cells by using a bacterial artificial chromosome system. J Virol. 78(13),7004-7015, 2004.

11. Kanda T, Otter M, and Wahl GM: Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering. J Cell Sci. 114(Pt 1),49-58, 2001.

12. Kanda T, Otter M, and Wahl GM: Coupling of mitotic chromosome tethering and replication competence in Epstein-Barr virus-based plasmids. Mol Cell Biol. 21(10),3576-3588, 2001.

13. Kanda T, and Wahl GM: The dynamics of acentric chromosomes in cancer cells revealed by GFP-based chromosome labeling strategies. J Cell Biochem Suppl. 35(107-114, 2000.

14. Kanda T, Sullivan KF, and Wahl GM: Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol. 8(7),377-385, 1998.

15. Shimizu N, Kanda T, and Wahl GM: Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet. 12(1),65-71, 1996.

16. Kanda T, Segawa K, Ohuchi N, Mori S, and Ito Y: Stimulation of polyomavirus DNA replication by wild-type p53 through the DNA-binding site. Mol Cell Biol. 14(4),2651-2663, 1994.